Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China.

Published

Journal Article

Human longevity is a complex heritable genetic trait. Based on substantial evidence from model organisms, it is clear that mitochondria play a pivotal role in aging and lifespan. However, the effects that mitochondrial genome variations have upon longevity and longevity-related phenotypes in Chuang people in China have yet to be established. By genotyping 15 variants for 10 haplogroups in 738 Chuang subjects, including 367 long-lived individuals and 371 controls, we found that haplogroup F was significantly associated with longevity in females of Zhuang population of China (p=0.003, OR: 2.01, 95%CI: 1.263-3.197). Additionally, haplogroup F was related to higher HDL levels (p<0.05) in long-lived individuals. Further analysis suggests that the non-synonymous variant m.13928G>C in haplogroup F was also associated with longevity in female Zhuang Chinese which might account for the beneficial effect of F.

Full Text

Duke Authors

Cited Authors

  • Feng, J; Zhang, J; Liu, M; Wan, G; Qi, K; Zheng, C; Lv, Z; Hu, C; Zeng, Y; Gregory, SG; Yang, Z

Published Date

  • December 2011

Published In

Volume / Issue

  • 46 / 12

Start / End Page

  • 987 - 993

PubMed ID

  • 21945877

Pubmed Central ID

  • 21945877

Electronic International Standard Serial Number (EISSN)

  • 1873-6815

Digital Object Identifier (DOI)

  • 10.1016/j.exger.2011.09.001

Language

  • eng

Conference Location

  • England