IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.

Published

Journal Article

Multiple sclerosis (MS) and type 1 diabetes (T1D) are organ-specific autoimmune disorders with significant heritability, part of which is conferred by shared alleles. For decades, the Human Leukocyte Antigen (HLA) complex was the only known susceptibility locus for both T1D and MS, but loci outside the HLA complex harboring risk alleles have been discovered and fully replicated. A genome-wide association scan for MS risk genes and candidate gene association studies have previously described the IL2RA gene region as a shared autoimmune locus. In order to investigate whether autoimmunity risk at IL2RA was due to distinct or shared alleles, we performed a genetic association study of three IL2RA variants in a DNA collection of up to 9,407 healthy controls, 2,420 MS, and 6,425 T1D subjects as well as 1,303 MS parent/child trios. Here, we report "allelic heterogeneity" at the IL2RA region between MS and T1D. We observe an allele associated with susceptibility to one disease and risk to the other, an allele that confers susceptibility to both diseases, and an allele that may only confer susceptibility to T1D. In addition, we tested the levels of soluble interleukin-2 receptor (sIL-2RA) in the serum from up to 69 healthy control subjects, 285 MS, and 1,317 T1D subjects. We demonstrate that multiple variants independently correlate with sIL-2RA levels.

Full Text

Duke Authors

Cited Authors

  • Maier, LM; Lowe, CE; Cooper, J; Downes, K; Anderson, DE; Severson, C; Clark, PM; Healy, B; Walker, N; Aubin, C; Oksenberg, JR; Hauser, SL; Compston, A; Sawcer, S; International Multiple Sclerosis Genetics Consortium, ; De Jager, PL; Wicker, LS; Todd, JA; Hafler, DA

Published Date

  • January 2, 2009

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • e1000322 -

PubMed ID

  • 19119414

Pubmed Central ID

  • 19119414

Electronic International Standard Serial Number (EISSN)

  • 1553-7404

International Standard Serial Number (ISSN)

  • 1553-7390

Digital Object Identifier (DOI)

  • 10.1371/journal.pgen.1000322

Language

  • eng