Selective control of physiological responses by temporally-patterned electrical stimulation of the canine vagus nerve.

Journal Article (Journal Article)

Vagus nerve stimulation (VNS) is effective for treating epilepsy and depression, and has emerging indications for anxiety and heart failure. However, stimulation-evoked side effects remain a challenge for long-term compliance. We investigated the feasibility of reducing VNS side effects by using a temporally-modified stimulation pattern. In 4 anesthetized canines, we measured changes in both the heart rate and evoked laryngeal muscle activity. Compared to baseline, we found that a 5% duty cycle (measured by the number of pulses per second of stimulation) could still evoke a 21% reduction in heart rate; whereas compared to continuous stimulation (3 mA, 300 μs pulsewidth, 20 Hz) the same 5% duty cycle reduced the evoked laryngeal muscle activity by 90%. The results of this study indicate that temporally-patterned stimulation may provide an effective tool for optimizing VNS therapy.

Full Text

Duke Authors

Cited Authors

  • Yoo, PB; Hincapie, JG; Hamann, JJ; Ruble, SB; Wolf, PD; Grill, WM

Published Date

  • January 2011

Published In

  • Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual International Conference

Volume / Issue

  • 2011 /

Start / End Page

  • 3107 - 3110

PubMed ID

  • 22254997

Electronic International Standard Serial Number (EISSN)

  • 2694-0604

International Standard Serial Number (ISSN)

  • 2375-7477

Digital Object Identifier (DOI)

  • 10.1109/iembs.2011.6090848


  • eng