Selective control of physiological responses by temporally-patterned electrical stimulation of the canine vagus nerve.


Journal Article

Vagus nerve stimulation (VNS) is effective for treating epilepsy and depression, and has emerging indications for anxiety and heart failure. However, stimulation-evoked side effects remain a challenge for long-term compliance. We investigated the feasibility of reducing VNS side effects by using a temporally-modified stimulation pattern. In 4 anesthetized canines, we measured changes in both the heart rate and evoked laryngeal muscle activity. Compared to baseline, we found that a 5% duty cycle (measured by the number of pulses per second of stimulation) could still evoke a 21% reduction in heart rate; whereas compared to continuous stimulation (3 mA, 300 μs pulsewidth, 20 Hz) the same 5% duty cycle reduced the evoked laryngeal muscle activity by 90%. The results of this study indicate that temporally-patterned stimulation may provide an effective tool for optimizing VNS therapy.

Full Text

Duke Authors

Cited Authors

  • Yoo, PB; Hincapie, JG; Hamann, JJ; Ruble, SB; Wolf, PD; Grill, WM

Published Date

  • January 2011

Published In

Volume / Issue

  • 2011 /

Start / End Page

  • 3107 - 3110

PubMed ID

  • 22254997

Pubmed Central ID

  • 22254997

International Standard Serial Number (ISSN)

  • 1557-170X

Digital Object Identifier (DOI)

  • 10.1109/iembs.2011.6090848


  • eng