Antidromic action potential propagation in branched axons

Journal Article

Electrical stimulation in the central nervous system can generate both orthodromic activity, by stimulation of local cells and passing axons, as well as antidromic activity, by stimulation of presynaptic axons and terminals. We used computational models to study antidromic action potential propagation in branched axons. Antidromic propagation occurred robustly, and action potentials traveled both antidromically into the primary segment as well as "orthodromically" into the terminal secondary segment. Thus, antidromic activation of axon terminals can, through axon collaterals, lead to widespread activation or inhibition of targets distant from the site of stimulation. © 2005 IEEE.

Full Text

Duke Authors

Cited Authors

  • Grill, WM; Robertson, MW

Published Date

  • December 1, 2005

Published In

  • 2nd International Ieee Embs Conference on Neural Engineering

Volume / Issue

  • 2005 /

Start / End Page

  • 183 - 185

Digital Object Identifier (DOI)

  • 10.1109/CNE.2005.1419585

Citation Source

  • Scopus