A urethral afferent mediated excitatory bladder reflex exists in humans.

Journal Article (Journal Article)

An excitatory reflex between urethral flow receptors and the bladder has been established in animals, but attempts to demonstrate this reflex in humans using urethral fluid flow have been inconclusive. Intraurethral electrical stimulation has recently been shown to generate bladder contractions in animals and was applied to study the presence of an excitatory urethra to bladder reflex in humans. The prostatic urethra was stimulated electrically via a catheter-based electrode in five men with complete spinal cord injury. Bladder contractions were generated in four of five individuals, however, only when the bladder volume was sufficiently large. These results demonstrate the presence of a volume dependent excitatory bladder reflex mediated by urethral afferent nerve fibers and the lumbosacral spinal cord.

Full Text

Duke Authors

Cited Authors

  • Gustafson, KJ; Creasey, GH; Grill, WM

Published Date

  • April 2004

Published In

Volume / Issue

  • 360 / 1-2

Start / End Page

  • 9 - 12

PubMed ID

  • 15082166

Electronic International Standard Serial Number (EISSN)

  • 1872-7972

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/j.neulet.2004.01.001


  • eng