Influence of the myelin sheath on excitation properties of nerve fibers

Journal Article (Journal Article)

The excitation and conduction properties of computer-based cable models of mammalian motor nerve fibers incorporating three different myelin representations were compared. The three myelin representations were a perfectly insulating single cable (model A), a finite impedance single cable (model B), and a finite impedance double cable (model C). Extracellular stimulation of the three models was used to study strength-duration, current-distance (I-X), conduction velocity (CV) properties. All three models had a chronaxie time (Tch) that was within the experimental range. Models B and C had increased threshold current as compared to model A, but each model had a slope to the I-X relationship that matched experimental results. Model B had a CV that matched experimental data while the CV of models A and C were above and below the experimental range, respectively. These results indicate that the presence of a finite impedance myelin sheath does influence the excitation properties of nerve fiber models and must be considered when using models for design of neural stimulation paradigms.

Full Text

Duke Authors

Cited Authors

  • Grill, WM; Richardson, AG; McIntyre, CC

Published Date

  • January 1, 2000

Published In

Volume / Issue

  • 3 /

Start / End Page

  • 1605 - 1607

International Standard Serial Number (ISSN)

  • 0589-1019

Digital Object Identifier (DOI)

  • 10.1109/IEMBS.2000.900380

Citation Source

  • Scopus