Oncolytic poliovirus against malignant glioma.

Published

Journal Article

In cancerous cells, physiologically tight regulation of protein synthesis is lost, contributing to uncontrolled growth and proliferation. We describe a novel experimental cancer therapy approach based on genetically recombinant poliovirus that targets an intriguing aberration of translation control in malignancy. This strategy is based on the confluence of several factors enabling specific and efficacious cancer cell targeting. Poliovirus naturally targets the vast majority of ectodermal/neuroectodermal cancers expressing its cellular receptor. Evidence from glioblastoma patients suggests that the poliovirus receptor is ectopically upregulated on tumor cells and may be associated with stem cell-like cancer cell populations and proliferating tumor vasculature. We exploit poliovirus' reliance on an unorthodox mechanism of protein synthesis initiation to selectively drive viral translation, propagation and cytotoxicity in glioblastoma. PVSRIPO, a prototype nonpathogenic poliovirus recombinant, is scheduled to enter clinical investigation against glioblastoma.

Full Text

Duke Authors

Cited Authors

  • Goetz, C; Dobrikova, E; Shveygert, M; Dobrikov, M; Gromeier, M

Published Date

  • September 2011

Published In

Volume / Issue

  • 6 / 9

Start / End Page

  • 1045 - 1058

PubMed ID

  • 21984883

Pubmed Central ID

  • 21984883

International Standard Serial Number (ISSN)

  • 1746-0794

Digital Object Identifier (DOI)

  • 10.2217/fvl.11.76

Language

  • eng

Conference Location

  • England