Isolation, structure and biological activities of platensimycin B4 from Streptomyces platensis.

Published

Journal Article

Platensimycin and platencin are inhibitors of FabF and FabF/H bacterial fatty acid synthesis enzymes, respectively. Discovery of natural congeners provides one of the ways to understand the relationship of chemical structure and biological function. Efforts to discover the natural analogs of platensimycin by chemical screening led to the isolation of platensimycin B(4), a glucoside congener of platensimycin. This analog showed significantly attenuated activity and critically defined the limited binding space around the aromatic ring and established the importance of the free phenolic and carboxyl group for the activity.

Full Text

Duke Authors

Cited Authors

  • Zhang, C; Ondeyka, J; Guan, Z; Dietrich, L; Burgess, B; Wang, J; Singh, SB

Published Date

  • December 2009

Published In

Volume / Issue

  • 62 / 12

Start / End Page

  • 699 - 702

PubMed ID

  • 19911028

Pubmed Central ID

  • 19911028

International Standard Serial Number (ISSN)

  • 0021-8820

Digital Object Identifier (DOI)

  • 10.1038/ja.2009.106

Language

  • eng

Conference Location

  • Japan