Isolation, structure, and coccidiostat activity of coccidiostatin A.

Journal Article (Journal Article)

Coccidiosis is one of the more common and costly diseases in poultry that is caused by various Eimeria species. In our quest to discover coccidiostats from natural products, we discovered a microbial fermentation extract that exhibited in vivo anticoccidial activity. Fractionation of this extract led to the discovery of two potent antiprotozoals, emecorrugatin A (1) and coccidiostatin A (2). The former compound exhibited only in vitro activity, whereas the latter new compound exhibited in vivo activity against Eimeria species in chickens at 150 ppm dosed in chicken feed. The isolation, structure elucidation, relative configuration, and activity of coccidiostatin A (2) are described.

Full Text

Duke Authors

Cited Authors

  • Jayasuriya, H; Guan, Z; Dombrowski, AW; Bills, GF; Polishook, JD; Jenkins, RG; Koch, L; Crumley, T; Tamas, T; Dubois, M; Misura, A; Darkin-Rattray, SJ; Gregory, L; Singh, SB

Published Date

  • August 2007

Published In

Volume / Issue

  • 70 / 8

Start / End Page

  • 1364 - 1367

PubMed ID

  • 17636951

International Standard Serial Number (ISSN)

  • 0163-3864

Digital Object Identifier (DOI)

  • 10.1021/np0700523

Language

  • eng

Conference Location

  • United States