Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity.
Journal Article (Journal Article)
Parasite cGMP-dependent protein kinase (PKG) is one of the validated biochemical targets for the treatment of coccidiosis. We screened our library of natural product extracts for inhibitors of parasite PKG for the discovery of anticoccidial leads. Terferol (1) and three new terphenyls (2, 3, and 4) were isolated using bioassay-guided fractionation of the microbial extract of a Phoma sp. by a high-throughput two-step isolation method employing LH-20 and reversed-phase HPLC. These compounds inhibited parasite PKG with IC(50) values in the range 0.9-5.8 microM.
- Zhang, C; Ondeyka, JG; Herath, KB; Guan, Z; Collado, J; Pelaez, F; Leavitt, PS; Gurnett, A; Nare, B; Liberator, P; Singh, SB
- April 2006
Volume / Issue
- 69 / 4
Start / End Page
- 710 - 712
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States