A new method for the synthesis of 1,4,5-oxadiazocines and its application in the structure modification of natural products
A new method for the synthesis of eight-membered heterocyclic 1,4,5-oxadiazocines has been described from β-diketone and β,β,β-triketone with an acidic α-hydrogen. The method entails the reaction of a di- or triketone with 2-hydroxyethylhydrazine and an aldehyde in the presence of acetic acid providing respectable yield. © 2005 Elsevier Ltd. All rights reserved.
Liu, W; Guan, Z; Singh, SB
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