Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity.
Publication
, Journal Article
Zhang, C; Ondeyka, JG; Herath, KB; Guan, Z; Collado, J; Platas, G; Pelaez, F; Leavitt, PS; Gurnett, A; Nare, B; Liberator, P; Singh, SB
Published in: J Nat Prod
April 2005
Parasite cGMP-dependent protein kinase (PKG) has been recently validated as a biochemical target for the treatment of coccidiosis. To discover new anticoccidial leads, we have screened our library of natural product extracts for inhibitors of parasite PKG. Bioassay-guided fractionation of the microbial extracts has led to the discovery of tenellones A (2) and B (3), two new highly substituted benzophenones. The isolation, structure, and activity of these compounds are described.
Duke Scholars
Published In
J Nat Prod
DOI
ISSN
0163-3864
Publication Date
April 2005
Volume
68
Issue
4
Start / End Page
611 / 613
Location
United States
Related Subject Headings
- Toxoplasma
- Spain
- Plants, Medicinal
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Fungi
- Enzyme Inhibitors
- Cyclic GMP-Dependent Protein Kinases
- Benzophenones
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhang, C., Ondeyka, J. G., Herath, K. B., Guan, Z., Collado, J., Platas, G., … Singh, S. B. (2005). Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity. J Nat Prod, 68(4), 611–613. https://doi.org/10.1021/np049591n
Zhang, Chaowei, John G. Ondeyka, Kithsiri B. Herath, Ziqiang Guan, Javier Collado, Gonzalo Platas, Fernando Pelaez, et al. “Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity.” J Nat Prod 68, no. 4 (April 2005): 611–13. https://doi.org/10.1021/np049591n.
Zhang C, Ondeyka JG, Herath KB, Guan Z, Collado J, Platas G, et al. Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity. J Nat Prod. 2005 Apr;68(4):611–3.
Zhang, Chaowei, et al. “Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity.” J Nat Prod, vol. 68, no. 4, Apr. 2005, pp. 611–13. Pubmed, doi:10.1021/np049591n.
Zhang C, Ondeyka JG, Herath KB, Guan Z, Collado J, Platas G, Pelaez F, Leavitt PS, Gurnett A, Nare B, Liberator P, Singh SB. Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity. J Nat Prod. 2005 Apr;68(4):611–613.
Published In
J Nat Prod
DOI
ISSN
0163-3864
Publication Date
April 2005
Volume
68
Issue
4
Start / End Page
611 / 613
Location
United States
Related Subject Headings
- Toxoplasma
- Spain
- Plants, Medicinal
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Fungi
- Enzyme Inhibitors
- Cyclic GMP-Dependent Protein Kinases
- Benzophenones
- Animals