Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity.
Journal Article (Journal Article)
Parasite cGMP-dependent protein kinase (PKG) has been recently validated as a biochemical target for the treatment of coccidiosis. To discover new anticoccidial leads, we have screened our library of natural product extracts for inhibitors of parasite PKG. Bioassay-guided fractionation of the microbial extracts has led to the discovery of tenellones A (2) and B (3), two new highly substituted benzophenones. The isolation, structure, and activity of these compounds are described.
Full Text
Duke Authors
Cited Authors
- Zhang, C; Ondeyka, JG; Herath, KB; Guan, Z; Collado, J; Platas, G; Pelaez, F; Leavitt, PS; Gurnett, A; Nare, B; Liberator, P; Singh, SB
Published Date
- April 2005
Published In
Volume / Issue
- 68 / 4
Start / End Page
- 611 - 613
PubMed ID
- 15844962
International Standard Serial Number (ISSN)
- 0163-3864
Digital Object Identifier (DOI)
- 10.1021/np049591n
Language
- eng
Conference Location
- United States