Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity.

Published

Journal Article

Parasite cGMP-dependent protein kinase (PKG) has been recently validated as a biochemical target for the treatment of coccidiosis. To discover new anticoccidial leads, we have screened our library of natural product extracts for inhibitors of parasite PKG. Bioassay-guided fractionation of the microbial extracts has led to the discovery of tenellones A (2) and B (3), two new highly substituted benzophenones. The isolation, structure, and activity of these compounds are described.

Full Text

Duke Authors

Cited Authors

  • Zhang, C; Ondeyka, JG; Herath, KB; Guan, Z; Collado, J; Platas, G; Pelaez, F; Leavitt, PS; Gurnett, A; Nare, B; Liberator, P; Singh, SB

Published Date

  • April 2005

Published In

Volume / Issue

  • 68 / 4

Start / End Page

  • 611 - 613

PubMed ID

  • 15844962

Pubmed Central ID

  • 15844962

Electronic International Standard Serial Number (EISSN)

  • 1520-6025

International Standard Serial Number (ISSN)

  • 0163-3864

Digital Object Identifier (DOI)

  • 10.1021/np049591n

Language

  • eng