Isolation and insecticidal activity of mellamide from Aspergillus melleus.

Journal Article (Journal Article)

Mellamide, a novel indole amide, was isolated from a fermentation of Aspergillus melleus using silica gel and high-performance liquid chromatographic methods. This allowed its separation from three known antiparasitic compounds (ochratoxin A, viomellin and xanthomegnin) also present in the potent extract. The structure was elucidated by (1)H, (13)C, COSY, DEPT, HMQC and HMBC NMR experiments. HR-FTMS aided in the molecular weight and formula determination. Mellamide showed in vitro insecticidal activity in bioassays against larvae of Lucilia sericata and Aedes egypti with LD(90) of 1,000 and 50 micro g/ml, respectively.

Full Text

Duke Authors

Cited Authors

  • Ondeyka, JG; Dombrowski, AW; Polishook, JP; Felcetto, T; Shoop, WL; Guan, Z; Singh, SB

Published Date

  • April 2003

Published In

Volume / Issue

  • 30 / 4

Start / End Page

  • 220 - 224

PubMed ID

  • 12687496

International Standard Serial Number (ISSN)

  • 1367-5435

Digital Object Identifier (DOI)

  • 10.1007/s10295-003-0048-y


  • eng

Conference Location

  • Germany