Isolation and structure elucidation of coleophomones A and B, novel inhibitors of bacterial cell wall transglycosylase

Journal Article (Journal Article)

The discovery, structure and absolute stereochemistry of coleophomones A and B are described, two structurally novel natural products that inhibit bacterial transglycosylase activity. Coleophomone A represents a new ring system, containing a highly condensed structure which undergoes a reversible retroaldol reaction to form coleophomone B. (C) 2000 Elsevier Science Ltd.

Full Text

Duke Authors

Cited Authors

  • Wilson, KE; Tsou, NN; Guan, Z; Ruby, CL; Pelaez, F; Gorrochategui, J; Vicente, F; Onishi, HR

Published Date

  • November 4, 2000

Published In

Volume / Issue

  • 41 / 45

Start / End Page

  • 8705 - 8709

International Standard Serial Number (ISSN)

  • 0040-4039

Digital Object Identifier (DOI)

  • 10.1016/S0040-4039(00)01532-X

Citation Source

  • Scopus