Stem cell-based therapies for osteoarthritis: challenges and opportunities.


Journal Article (Review)

Regenerative medicine offers the exciting potential of developing alternatives to total joint replacement for treating osteoarthritis. In this article, we highlight recent work that addresses key challenges of stem cell-based therapies for osteoarthritis and provide examples of innovative ways in which stem cells can aid in the treatment of osteoarthritis.Significant progress has been made in understanding the challenges to successful stem cell therapy, such as the effects of age or disease on stem cell properties, altered stem cell function due to an inflammatory joint environment and phenotypic instability in vivo. Novel scaffold designs have been shown to enhance the mechanical properties of tissue-engineered cartilage and have also improved the integration of newly formed tissue within the joint. Emerging strategies such as injecting stem cells directly into the joint, manipulating endogenous stem cells to enhance regenerative capacity and utilizing stem cells for drug discovery have expanded the potential uses of stem cells in treating osteoarthritis.Several recent studies have greatly advanced the development and preclinical evaluation of potential stem cell-based treatments for osteoarthritis through novel approaches focused on cell therapy, tissue engineering and drug discovery.

Full Text

Cited Authors

  • Diekman, BO; Guilak, F

Published Date

  • January 2013

Published In

Volume / Issue

  • 25 / 1

Start / End Page

  • 119 - 126

PubMed ID

  • 23190869

Pubmed Central ID

  • 23190869

Electronic International Standard Serial Number (EISSN)

  • 1531-6963

International Standard Serial Number (ISSN)

  • 1040-8711

Digital Object Identifier (DOI)

  • 10.1097/bor.0b013e32835aa28d


  • eng