Diet-induced obesity alters the differentiation potential of stem cells isolated from bone marrow, adipose tissue and infrapatellar fat pad: the effects of free fatty acids.

Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.

Obesity is a major risk factor for several musculoskeletal conditions that are characterized by an imbalance of tissue remodeling. Adult stem cells are closely associated with the remodeling and potential repair of several mesodermally derived tissues such as fat, bone and cartilage. We hypothesized that obesity would alter the frequency, proliferation, multipotency and immunophenotype of adult stem cells from a variety of tissues.

Full Text

Duke Authors

Cited Authors

  • Wu, CL; Diekman, BO; Jain, D; Guilak, F

Published Date

  • August 2013

Published In

Volume / Issue

  • 37 / 8

Start / End Page

  • 1079 - 1087

PubMed ID

  • 23164698

Electronic International Standard Serial Number (EISSN)

  • 1476-5497

Digital Object Identifier (DOI)

  • 10.1038/ijo.2012.171

Language

  • eng

Citation Source

  • PubMed