Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice.
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Obesity and joint injury are primary risk factors for osteoarthritis (OA) that involve potential alterations in the biomechanical and inflammatory environments of the joint. Posttraumatic arthritis is a frequent long-term complication of intraarticular fractures. Obesity has been linked to primary OA and may potentially contribute to the development of posttraumatic arthritis by a variety of mechanisms. The objectives of this study were to determine whether diet-induced obesity influences the severity of posttraumatic arthritis in mice and to examine the interrelationships between joint degeneration and serum levels of the inflammatory cytokines and adipokines that are involved in this response.
Louer, CR; Furman, BD; Huebner, JL; Kraus, VB; Olson, SA; Guilak, F
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