Concise review: Adipose-derived stromal vascular fraction cells and stem cells: let's not get lost in translation.

Journal Academic Article, Review

Subcutaneous fat has emerged as an alternative tissue source for stromal/stem cells in regenerative medicine. Over the past decade, international research efforts have established a wealth of basic science and preclinical evidence regarding the differentiation potential and regenerative properties of both freshly processed, heterogeneous stromal vascular fraction cells and culture expanded, relatively homogeneous adipose-derived stromal/stem cells. The stage has been set for clinicians to translate adipose-derived cells from the bench to the bedside; however, this process will involve "development" steps that fall outside of traditional "hypothesis-driven, mechanism-based" paradigm. This concise review examines the next stages of the development process for therapeutic applications of adipose-derived cells and highlights the current state of the art regarding clinical trials. It is recommended that the experiments addressing these issues be reported comprehensively in the peer-review literature. This transparency will accelerate the standardization and reproducibility of adipose-derived cell therapies with respect to their efficacy and safety.

Full Text

Duke Authors

Cited Authors

  • Gimble, JM; Bunnell, BA; Chiu, ES; Guilak, F

Published Date

  • May 2011

Published In

Volume / Issue

  • 29 / 5

Start / End Page

  • 749 - 754

PubMed ID

  • 21433220

Electronic International Standard Serial Number (EISSN)

  • 1549-4918

Digital Object Identifier (DOI)

  • 10.1002/stem.629

Language

  • eng

Citation Source

  • PubMed