Engineered cartilage using primary chondrocytes cultured in a porous cartilage-derived matrix.
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
To investigate the cell growth, matrix accumulation and mechanical properties of neocartilage formed by human or porcine articular chondrocytes on a porous, porcine cartilage-derived matrix (CDM) for use in cartilage tissue engineering. MATERIALS & Methods: We examined the physical properties, cell infiltration and matrix accumulation in different formulations of CDM and selected a CDM made of homogenized cartilage slurry as an appropriate scaffold for long-term culture of human and porcine articular chondrocytes.
Cheng, NC; Estes, BT; Young, TH; Guilak, F
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