Homing in on a biological joint replacement.


Journal Article

The use of tissue engineering therapies for treating damaged articular cartilage has traditionally focused on cell-based therapies for the repair of focal chondral or osteochondral defects. A recent study by Lee and colleagues in the Lancet shows exciting proof-of-concept that an acellular scaffold containing transforming growth factor beta 3 can induce homing of cells that regenerate a hyaline-like cartilage surface. These findings provide a glimpse into the possibility that tissue engineering may in fact provide the means for regeneration of an entire joint surface, beyond a simple focal defect in the articular cartilage.

Full Text

Cited Authors

  • Guilak, F

Published Date

  • January 2010

Published In

Volume / Issue

  • 1 / 5

Start / End Page

  • 40 -

PubMed ID

  • 21156083

Pubmed Central ID

  • 21156083

Electronic International Standard Serial Number (EISSN)

  • 1757-6512

International Standard Serial Number (ISSN)

  • 1757-6512

Digital Object Identifier (DOI)

  • 10.1186/scrt40


  • eng