Control of stem cell fate by physical interactions with the extracellular matrix.

Journal Article (Journal Article;Review)

A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at the nanoscale, ECM mechanical properties, and the transmission of mechanical or other biophysical factors to the cell. Here, we review some of the physical processes by which cues from the ECM can influence stem cell fate, with particular relevance to the use of stem cells in tissue engineering and regenerative medicine.

Full Text

Duke Authors

Cited Authors

  • Guilak, F; Cohen, DM; Estes, BT; Gimble, JM; Liedtke, W; Chen, CS

Published Date

  • July 2, 2009

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 17 - 26

PubMed ID

  • 19570510

Pubmed Central ID

  • PMC2768283

Electronic International Standard Serial Number (EISSN)

  • 1875-9777

Digital Object Identifier (DOI)

  • 10.1016/j.stem.2009.06.016


  • eng

Conference Location

  • United States