Control of stem cell fate by physical interactions with the extracellular matrix.
Journal Article (Journal Article;Review)
A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at the nanoscale, ECM mechanical properties, and the transmission of mechanical or other biophysical factors to the cell. Here, we review some of the physical processes by which cues from the ECM can influence stem cell fate, with particular relevance to the use of stem cells in tissue engineering and regenerative medicine.
Full Text
Duke Authors
Cited Authors
- Guilak, F; Cohen, DM; Estes, BT; Gimble, JM; Liedtke, W; Chen, CS
Published Date
- July 2, 2009
Published In
Volume / Issue
- 5 / 1
Start / End Page
- 17 - 26
PubMed ID
- 19570510
Pubmed Central ID
- PMC2768283
Electronic International Standard Serial Number (EISSN)
- 1875-9777
Digital Object Identifier (DOI)
- 10.1016/j.stem.2009.06.016
Language
- eng
Conference Location
- United States