Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes.
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Transient receptor potential vanilloid 4 (TRPV4) is a Ca(2+)-permeable channel that can be gated by tonicity (osmolarity) and mechanical stimuli. Chondrocytes, the cells in cartilage, respond to their osmotic and mechanical environments; however, the molecular basis of this signal transduction is not fully understood. This study was undertaken to demonstrate the presence and functionality of TRPV4 in chondrocytes.
Phan, MN; Leddy, HA; Votta, BJ; Kumar, S; Levy, DS; Lipshutz, DB; Lee, SH; Liedtke, W; Guilak, F
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