Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes.

Journal Academic Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

Transient receptor potential vanilloid 4 (TRPV4) is a Ca(2+)-permeable channel that can be gated by tonicity (osmolarity) and mechanical stimuli. Chondrocytes, the cells in cartilage, respond to their osmotic and mechanical environments; however, the molecular basis of this signal transduction is not fully understood. This study was undertaken to demonstrate the presence and functionality of TRPV4 in chondrocytes.

Full Text

Duke Authors

Cited Authors

  • Phan, MN; Leddy, HA; Votta, BJ; Kumar, S; Levy, DS; Lipshutz, DB; Lee, SH; Liedtke, W; Guilak, F

Published Date

  • October 2009

Published In

Volume / Issue

  • 60 / 10

Start / End Page

  • 3028 - 3037

PubMed ID

  • 19790068

International Standard Serial Number (ISSN)

  • 0004-3591

Digital Object Identifier (DOI)

  • 10.1002/art.24799


  • eng

Citation Source

  • PubMed