Interleukin-1 inhibits osmotically induced calcium signaling and volume regulation in articular chondrocytes.

Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

Articular chondrocytes respond to osmotic stress with transient changes in cell volume and the intracellular concentration of calcium ion ([Ca(2+)](i)). The goal of this study was to examine the hypothesis that interleukin-1 (IL-1), a pro-inflammatory cytokine associated with osteoarthritis, influences osmotically induced Ca(2+) signaling.

Full Text

Duke Authors

Cited Authors

  • Pritchard, S; Votta, BJ; Kumar, S; Guilak, F

Published Date

  • December 2008

Published In

Volume / Issue

  • 16 / 12

Start / End Page

  • 1466 - 1473

PubMed ID

  • 18495501

Electronic International Standard Serial Number (EISSN)

  • 1522-9653

Digital Object Identifier (DOI)

  • 10.1016/j.joca.2008.04.003


  • eng

Citation Source

  • PubMed