Interleukin-1 inhibits osmotically induced calcium signaling and volume regulation in articular chondrocytes.
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Articular chondrocytes respond to osmotic stress with transient changes in cell volume and the intracellular concentration of calcium ion ([Ca(2+)](i)). The goal of this study was to examine the hypothesis that interleukin-1 (IL-1), a pro-inflammatory cytokine associated with osteoarthritis, influences osmotically induced Ca(2+) signaling.
Pritchard, S; Votta, BJ; Kumar, S; Guilak, F
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