In vitro Differentiation Potential of Mesenchymal Stem Cells.


SUMMARY: Mesenchymal stem cells (MSCs) represent a class of multipotent progenitor cells that have been isolated from multiple tissue sites. Of these, adipose tissue and bone marrow offer advantages in terms of access, abundance, and the extent of their documentation in the literature. This review focuses on the in vitro differentiation capability of cells derived from adult human tissue. Multiple, independent studies have demonstrated that MSCs can commit to mesodermal (adipocyte, chondrocyte, hematopoietic support, myocyte, osteoblast, tenocyte), ectodermal (epithelial, glial, neural), and endodermal (hepatocyte, islet cell) lineages. The limitations and promises of these studies in the context of tissue engineering are discussed.

Full Text

Duke Authors

Cited Authors

  • Gimble, JM; Guilak, F; Nuttall, ME; Sathishkumar, S; Vidal, M; Bunnell, BA

Published Date

  • 2008

Published In

Volume / Issue

  • 35 / 3

Start / End Page

  • 228 - 238

PubMed ID

  • 21547120

International Standard Serial Number (ISSN)

  • 1660-3796

Digital Object Identifier (DOI)

  • 10.1159/000124281


  • ENG

Citation Source

  • PubMed