Application of a Three-Dimensional Poroelastic BEM to Modeling the Biphasic Mechanics of Cell-Matrix Interactions in Articular Cartilage (REVISION).

JOURNAL ARTICLE

Articular cartilage exhibits viscoelasticity in response to mechanical loading that is well described using biphasic or poroelastic continuum models. To date, boundary element methods (BEMs) have not been employed in modeling biphasic tissue mechanics. A three dimensional direct poroelastic BEM, formulated in the Laplace transform domain, is applied to modeling stress relaxation in cartilage. Macroscopic stress relaxation of a poroelastic cylinder in uni-axial confined compression is simulated and validated against a theoretical solution. Microscopic cell deformation due to poroelastic stress relaxation is also modeled. An extended Laplace inversion method is employed to accurately represent mechanical responses in the time domain.

Full Text

Duke Authors

Cited Authors

  • Haider, MA; Guilak, F

Published Date

  • June 15, 2007

Published In

Volume / Issue

  • 196 / 31-32

Start / End Page

  • 2999 - 3010

PubMed ID

  • 19851478

International Standard Serial Number (ISSN)

  • 0045-7825

Digital Object Identifier (DOI)

  • 10.1016/j.cma.2006.08.020

Language

  • ENG

Citation Source

  • PubMed