Evaluation of clear corneal wound dynamics with contrast-enhanced spectral-domain optical coherence tomography.
BACKGROUND AND OBJECTIVE: To evaluate wound morphology and integrity using contrast-enhanced spectral-domain optical coherence tomography (SD-OCT). PATIENTS AND METHODS: Eighteen patients (18 eyes) undergoing unilateral routine cataract surgery were enrolled. SD-OCT imaging of the corneal wound was performed immediately following cataract surgery and on postoperative day 1. A topical contrast agent, prednisolone acetate 1%, was used to help evaluate wound integrity. OCT features of the corneal incision and changes in wound interface reflectivity after administration of topical prednisolone acetate 1% were analyzed. Main outcome measures were quantitative and qualitative description of wound morphology and contrast enhancement of the wound interface. RESULTS: Internal wound gape was found in 89% of eyes. Gape area decreased by 43% from days 0 to 1 (462 vs 273 μm(2); P < .01). Contrast enhancement at the wound interface was seen in 56% of eyes on day 0 compared to 17% on day 1 following application of prednisolone acetate 1% (P < .05). Decreased intraocular pressure correlated with increased contrast enhancement (P < .05). CONCLUSION: Wound morphology evolves during the early postoperative period. Wound gape and ingress of a topical contrast agent decrease during the first 24 hours following surgery. Contrast enhancement at the wound interface increases as the intraocular pressure decreases.
Duke Scholars
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Wound Healing
- Tomography, Optical Coherence
- Surgical Wound Dehiscence
- Prednisolone
- Phacoemulsification
- Ophthalmology & Optometry
- Male
- Lens Implantation, Intraocular
- Intraocular Pressure
- Humans
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Wound Healing
- Tomography, Optical Coherence
- Surgical Wound Dehiscence
- Prednisolone
- Phacoemulsification
- Ophthalmology & Optometry
- Male
- Lens Implantation, Intraocular
- Intraocular Pressure
- Humans