Amiprilose hydrochloride inhibits porcine aortic smooth muscle cell proliferation in vitro.

Published

Journal Article

The effect of amiprilose hydrochloride, a synthetic monosaccharide, on smooth muscle cell proliferation was studied in vitro. Using porcine aortic smooth muscle cell cultures, amiprilose significantly inhibited cell proliferation in a dose-dependent fashion at concentrations of 0.5-1.0 mg/ml. This antiproliferative effect was reversible upon removing amiprilose by cell washing and adding fresh media. Pretreating cells with amiprilose before serum stimulation did not affect subsequent growth. Inhibition of proliferation occurred when amiprilose was added up to 48 hours after serum stimulation. As such, amiprilose deserves further investigation as a potential therapeutic agent in preventing restenosis after angioplasty.

Full Text

Duke Authors

Cited Authors

  • Siegel, CO; Churchill, DA; Vu, L; Guyton, JR; Minor, ST; Raizner, AE

Published Date

  • January 1, 1994

Published In

Volume / Issue

  • 21 / 2

Start / End Page

  • 114 - 123

PubMed ID

  • 7695482

Pubmed Central ID

  • 7695482

International Standard Serial Number (ISSN)

  • 0098-6127

Language

  • eng