The arterial wall and the atherosclerotic lesion.

Journal Article (Journal Article;Review)

The role of the lipid-rich core region in atherogenesis is beginning to be understood, from its inception in early lesions to its catastrophic effects in promoting plaque rupture in late lesions. Besides the lipid-rich core, recent studies on human and animal atherosclerosis have drawn attention to atherogenic lipoproteins larger than LDL, unesterified cholesterol in lesions, apolipoprotein E as an antiatherogenic factor, macrophages as atherogenic effector cells, and unexpectedly slow rates of smooth muscle cell proliferation.

Full Text

Duke Authors

Cited Authors

  • Guyton, JR

Published Date

  • October 1994

Published In

Volume / Issue

  • 5 / 5

Start / End Page

  • 376 - 381

PubMed ID

  • 7858913

International Standard Serial Number (ISSN)

  • 0957-9672

Digital Object Identifier (DOI)

  • 10.1097/00041433-199410000-00010


  • eng

Conference Location

  • England