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Human aortic fibrolipid lesions. Immunochemical localization of apolipoprotein B and apolipoprotein A.

Publication ,  Journal Article
Bocan, TM; Brown, SA; Guyton, JR
Published in: Arteriosclerosis
1988

Comparative localization of apolipoproteins (apo) B and A in small, raised fibrolipid lesions was performed to determine whether low density lipoproteins (LDL) and high density lipoproteins (HDL) may be involved in the formation of the earliest identifiable lipid-rich core regions found in atherosclerotic fibrous plaques. Apo B was observed associated with the superficial layer of foam cells in collagenous areas of the lesion cap and within the lipid-rich core region. The lipid-rich core region was well-circumscribed by an intense band of apo B staining along both luminal and medial aspects. Apo A staining was confined to the noncellular elements of the fibrolipid lesion. Collagenous areas were speckled with fine, punctate granules of immunoreactive apo A. A homogeneous, granular apo A staining pattern was characteristic throughout the core region. With these data from a relatively early lesion in the development of the atherosclerotic fibrous plaque, we conclude that: 1) both LDL and HDL can accumulate in the lipid-rich core region since no preferential staining for apo B over apo A was observed in this region, and 2) the paucity of cell-associated apo A staining in small fibrolipid lesions suggests that HDL interacts with the arterial wall differently than does HDL.

Duke Scholars

Published In

Arteriosclerosis

DOI

ISSN

0276-5047

Publication Date

1988

Volume

8

Issue

5

Start / End Page

499 / 508

Location

United States

Related Subject Headings

  • Staining and Labeling
  • Middle Aged
  • Immunohistochemistry
  • Humans
  • Child
  • Arteriosclerosis
  • Apolipoproteins B
  • Apolipoproteins A
  • Aorta
  • Antibody Specificity
 

Citation

APA
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ICMJE
MLA
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Bocan, T. M., Brown, S. A., & Guyton, J. R. (1988). Human aortic fibrolipid lesions. Immunochemical localization of apolipoprotein B and apolipoprotein A. Arteriosclerosis, 8(5), 499–508. https://doi.org/10.1161/01.atv.8.5.499
Bocan, T. M., S. A. Brown, and J. R. Guyton. “Human aortic fibrolipid lesions. Immunochemical localization of apolipoprotein B and apolipoprotein A.Arteriosclerosis 8, no. 5 (1988): 499–508. https://doi.org/10.1161/01.atv.8.5.499.
Bocan TM, Brown SA, Guyton JR. Human aortic fibrolipid lesions. Immunochemical localization of apolipoprotein B and apolipoprotein A. Arteriosclerosis. 1988;8(5):499–508.
Bocan, T. M., et al. “Human aortic fibrolipid lesions. Immunochemical localization of apolipoprotein B and apolipoprotein A.Arteriosclerosis, vol. 8, no. 5, 1988, pp. 499–508. Pubmed, doi:10.1161/01.atv.8.5.499.
Bocan TM, Brown SA, Guyton JR. Human aortic fibrolipid lesions. Immunochemical localization of apolipoprotein B and apolipoprotein A. Arteriosclerosis. 1988;8(5):499–508.

Published In

Arteriosclerosis

DOI

ISSN

0276-5047

Publication Date

1988

Volume

8

Issue

5

Start / End Page

499 / 508

Location

United States

Related Subject Headings

  • Staining and Labeling
  • Middle Aged
  • Immunohistochemistry
  • Humans
  • Child
  • Arteriosclerosis
  • Apolipoproteins B
  • Apolipoproteins A
  • Aorta
  • Antibody Specificity