Ensuring the safe use of genomic medicine in children.

Journal Article (Journal Article)

Several clinical guidelines recommend that genetic testing in children be limited to tests with immediate clinical benefit. However, use of genome risk profiling will not likely meet this requirement, as the benefits are anticipated to be years away. Children who are at higher risk, though, will benefit the most from early initiation of treatment or interventions. The shift in benefit from immediate to long-term benefit warrants a reevaluation of the current practices of testing in children. In this commentary, the authors advocate the use of genomic risk profiling to identify children at increased risk who would benefit from early intervention, but recognize that its integration in clinical practice for this population will require a more nuanced approach to delivery and follow-up. In particular, the importance of counseling, context, consent, communication, and follow-up in the delivery of genomic risk testing to children and adolescents is highlighted.

Full Text

Duke Authors

Cited Authors

  • Haga, SB; Terry, SF

Published Date

  • September 2009

Published In

Volume / Issue

  • 48 / 7

Start / End Page

  • 703 - 708

PubMed ID

  • 19448129

Electronic International Standard Serial Number (EISSN)

  • 1938-2707

Digital Object Identifier (DOI)

  • 10.1177/0009922809335736


  • eng

Conference Location

  • United States