Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids.


Journal Article

Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and polymorphisms in the ZAG gene in relation to serum lipids in man. Serum levels of ZAG correlated with serum levels of cholesterol (P = .00088) in healthy subjects and during weight loss (P = .059). The ZAG genotype was associated with total cholesterol (P = .014) and low-density lipoprotein cholesterol (P = .026) in healthy subjects, and the associations were replicated in an additional cohort (P = .0017 and P = .060, respectively). Our data indicate that ZAG plays a role in lipid metabolism.

Full Text

Duke Authors

Cited Authors

  • Olofsson, LE; Olsson, B; Lystig, T; Jacobson, P; Jernås, M; Sjöholm, K; Gummesson, A; Sjöström, L; Eriksson, P; Hamsten, A; Hale, LP; Thelle, DS; Carlsson, B; Carlsson, LMS

Published Date

  • September 2010

Published In

Volume / Issue

  • 59 / 9

Start / End Page

  • 1316 - 1318

PubMed ID

  • 20070991

Pubmed Central ID

  • 20070991

Electronic International Standard Serial Number (EISSN)

  • 1532-8600

Digital Object Identifier (DOI)

  • 10.1016/j.metabol.2009.12.006


  • eng

Conference Location

  • United States