Immunopathological and clinical studies in herpes gestationis.

Journal Article (Journal Article)

Herpes gestationis is a recurring pruritic, vesiculobullous disease of pregnancy and puerperium. Recently, Lawley et al (1979) reported a high frequency (38 per cent) of fetal morbidity and mortality in 40 cases of immunologically proven herpes gestationis. This study was undertaken to determine whether the antibody to skin basement membrane (found in most patients with herpes gestationis) is able to bind to the placenta basement membranes and thereby to threaten the pregnancy. We were unable to detect this antibody in the placental basement membranes of a patient with herpes gestationis, nor could we demonstrate that the anti-basement membrane antibody, found in the sera of herpes gestationis patients, binds to homologous or autologous placentas and fetal membranes. The importance of an accurate diagnosis and appropriate treatment of this condition is discussed.

Full Text

Duke Authors

Cited Authors

  • Foidart, JM; Yaar, M; Hall, R; Gaspard, U; Katz, SI

Published Date

  • February 1, 1981

Published In

Volume / Issue

  • 88 / 2

Start / End Page

  • 153 - 159

PubMed ID

  • 7006677

Pubmed Central ID

  • 7006677

International Standard Serial Number (ISSN)

  • 0306-5456

Digital Object Identifier (DOI)

  • 10.1111/j.1471-0528.1981.tb00961.x

Language

  • eng

Conference Location

  • England