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The organization of the lateral posterior nucleus of the golden hamster after neonatal superior colliculus lesions.

Publication ,  Journal Article
Crain, BJ; Hall, WC
Published in: J Comp Neurol
September 15, 1980

The reorganization of the adult hamster's lateral posterior nucleus after neonatal superior colliculus lesions was studied using primarily light and electron microscopic degeneration techniques. Two types of experiments were conducted. First, the distributions of the remaining afferents from the contralateral superior colliculus, the cotralateral retina, and the ipsilateral posterior neocortex were determined using the Fink-Heimer ('67) technique. Normally the projections from the contralateral superior colliculus and retina are sparse and restricted to small areas in the rostrolateral subdivision. After neonatal lesions of the ipsilateral colliculus, however, these two minor projections greatly increase in density and expand to share a common border. In contrast, the normal projection from the posterior neocortex is dense throughout the rostrolateral subdivision. After a neonatal colliculus lesion, however, this projection is greatly decreased in the region occupied by the optic tract terminals. Second, the ultrastructural organizatin of the rostrolateral subdivision was studied in adult animals whhich had received neonatal colliculus lesions. Normally, this region is characterized by synaptic clusters in which numerous medium-sized terminals (M-terminals), almost all from the ipsilateral colliculus, synapse around the shaft of a large central dendrite. The contralateral colliculus and retina normally contribute only a few M-terminals. After a neonatal colliculus lesion, typical clusters still form, but now the expanded projections from the contralateral colliculus and retina contribute numerous M-terminals. The cortex does not contribute M-terminals in either normal or experimental animals. These results suggest that the afferents to the rostrolateral subdivision normally compete for synaptic space. The various factors that might be involved in determining the outcome of such competition are discussed.

Duke Scholars

Published In

J Comp Neurol

DOI

ISSN

0021-9967

Publication Date

September 15, 1980

Volume

193

Issue

2

Start / End Page

383 / 401

Location

United States

Related Subject Headings

  • Visual Pathways
  • Visual Cortex
  • Synapses
  • Superior Colliculi
  • Retina
  • Neurology & Neurosurgery
  • Nerve Regeneration
  • Microscopy, Electron
  • Mesocricetus
  • Geniculate Bodies
 

Citation

APA
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ICMJE
MLA
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Crain, B. J., & Hall, W. C. (1980). The organization of the lateral posterior nucleus of the golden hamster after neonatal superior colliculus lesions. J Comp Neurol, 193(2), 383–401. https://doi.org/10.1002/cne.901930206
Crain, B. J., and W. C. Hall. “The organization of the lateral posterior nucleus of the golden hamster after neonatal superior colliculus lesions.J Comp Neurol 193, no. 2 (September 15, 1980): 383–401. https://doi.org/10.1002/cne.901930206.
Crain, B. J., and W. C. Hall. “The organization of the lateral posterior nucleus of the golden hamster after neonatal superior colliculus lesions.J Comp Neurol, vol. 193, no. 2, Sept. 1980, pp. 383–401. Pubmed, doi:10.1002/cne.901930206.
Journal cover image

Published In

J Comp Neurol

DOI

ISSN

0021-9967

Publication Date

September 15, 1980

Volume

193

Issue

2

Start / End Page

383 / 401

Location

United States

Related Subject Headings

  • Visual Pathways
  • Visual Cortex
  • Synapses
  • Superior Colliculi
  • Retina
  • Neurology & Neurosurgery
  • Nerve Regeneration
  • Microscopy, Electron
  • Mesocricetus
  • Geniculate Bodies