Modulation of vasopressin-elicited water transport by trafficking of aquaporin2-containing vesicles.

Published

Journal Article (Review)

Vasopressin or AVP regulates water reabsorption by the kidney inner medullary collecting duct (IMCD) through the insertion and removal of aquaporin (AQP) 2 water channels into the IMCD apical membrane. AVP-elicited trafficking of AQP2 with the apical membrane occurs via a specialized population of vesicles that resemble synaptic vesicles in neurons. AQP2 vesicles and the IMCD apical membrane contain homologs of vesicle-targeting and signal transduction proteins found in neurons. Expression studies of AQP2, including human AQP2 mutants, suggest that the carboxyl-terminal domain of AQP2 is important in AQP2 trafficking, particularly as a site for cAMP-dependent protein kinase phosphorylation. These present data reveal that IMCD cells possess a complex integrated-signaling and vesicle-trafficking machinery that provides integration of AVP-elicited water transport with many other parameters within the IMCD cell as well as kidney.

Full Text

Duke Authors

Cited Authors

  • Ward, DT; Hammond, TG; Harris, HW

Published Date

  • 1999

Published In

Volume / Issue

  • 61 /

Start / End Page

  • 683 - 697

PubMed ID

  • 10099706

Pubmed Central ID

  • 10099706

International Standard Serial Number (ISSN)

  • 0066-4278

Digital Object Identifier (DOI)

  • 10.1146/annurev.physiol.61.1.683

Language

  • eng

Conference Location

  • United States