Neural correlates of dementia: regional brain metabolism (FDG-PET) and the CERAD neuropsychological battery.
The present Investigation examined the biological correlates of the cognitive deficits of Alzheimer's disease and related dementias using the neuropsychological assessment battery of the Consortium to Establish a Registry of Alzheimer's Disease (CERAD) and positron emission tomography (PET). Resting state cerebral glucose metabolism was measured using the labelled radiotracer, [18F] Fluoro-2-deoxyglucose (FDG), in a sample of patients with mild to moderate dementia (n = 66). Specific and predictable relationships were seen between regional brain metabolism (left and right, frontal, temporal, and parietal lobes) and the neuropsychological measures of verbal fluency, constructional praxis, and verbal list learning. On tests of naming and delayed verbal recall only diminished FDG uptake in the left frontal lobe and the left temporal lobe, respectively, approached significance. This study demonstrates the expected relationships between neuropsychological performance and regional cerebral metabolism, thereby providing support for the CERAD battery as a valid measure in the clinical evaluation of dementia and for the use of FDG-PET in brain-behavior studies of dementia.
Duke Scholars
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- Clinical Psychology
- 5203 Clinical and health psychology
- 5202 Biological psychology
- 5201 Applied and developmental psychology
- 1702 Cognitive Sciences
- 1701 Psychology
- 1109 Neurosciences
Citation
Published In
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Clinical Psychology
- 5203 Clinical and health psychology
- 5202 Biological psychology
- 5201 Applied and developmental psychology
- 1702 Cognitive Sciences
- 1701 Psychology
- 1109 Neurosciences