Development of a new dyspepsia impact scale: the Nepean Dyspepsia Index.

Journal Article (Journal Article)

BACKGROUND: There is not at present a suitable disease-specific health-related quality of life instrument for uninvestigated dyspepsia and functional (non-ulcer) dyspepsia. AIM: To develop a new multi-dimensional disease-specific instrument. METHODS: The Nepean Dyspepsia Index (NDI) was designed to measure impairment of a subject's ability to engage in relevant aspects of their life and also their enjoyment of these aspects; in addition, the individual importance of each aspect is assessed. A 42-item quality of life measure was developed and tested, both in out-patients presenting to general practice with upper gastrointestinal complaints (n = 113) and in a randomly chosen population-based sample (n = 347). RESULTS: Adequate face and content validity was documented by an expert panel. Factor analysis identified four clinically relevant subscales: interference with activities of daily living, work, enjoyment of life and emotional well-being; lack of knowledge and control over the illness; disturbance to eating or drinking; and disturbance to sleep because of dyspepsia. These scales had high internal consistency. Both symptoms and the quality of life scores discriminated dyspepsia from health. CONCLUSION: The Nepean Dyspepsia Index is a reliable and valid disease-specific index for dyspepsia, measuring symptoms and health-related quality of life.

Full Text

Duke Authors

Cited Authors

  • Talley, NJ; Haque, M; Wyeth, JW; Stace, NH; Tytgat, GN; Stanghellini, V; Holtmann, G; Verlinden, M; Jones, M

Published Date

  • February 1999

Published In

Volume / Issue

  • 13 / 2

Start / End Page

  • 225 - 235

PubMed ID

  • 10102954

International Standard Serial Number (ISSN)

  • 0269-2813

Digital Object Identifier (DOI)

  • 10.1046/j.1365-2036.1999.00445.x


  • eng

Conference Location

  • England