Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype.

Journal Article (Journal Article)


Studies in humans and in animals have demonstrated that a network of brain regions is involved in performance of declarative and recognition memory tasks. This network includes the hippocampal formation (HF) as well as the ventrolateral prefrontal cortex (VLPFC). Studies in animals have suggested that the relationship between these brain regions is strongly modulated by dopamine.


Using fMRI in healthy humans matched for a series of demographic and genetic variables, we studied the effect of the COMT val158met polymorphism on function of HF and VLPFC as well as on their functional coupling during recognition memory.


The COMT Val allele was associated with: relatively poorer performance at retrieval; reduced recruitment of neuronal resources in HF and increased recruitment in VLPFC during both encoding and retrieval; and unfavorable functional coupling between these two regions at retrieval. Moreover, functional coupling during retrieval was predictive of behavioral accuracy.


These results shed new light on individual differences in responsivity and connectivity between HF and VLPFC related to genetic modulation of dopamine, a mechanism accounting at least in part for individual differences in recognition memory performance.

Full Text

Duke Authors

Cited Authors

  • Bertolino, A; Rubino, V; Sambataro, F; Blasi, G; Latorre, V; Fazio, L; Caforio, G; Petruzzella, V; Kolachana, B; Hariri, A; Meyer-Lindenberg, A; Nardini, M; Weinberger, DR; Scarabino, T

Published Date

  • December 2006

Published In

Volume / Issue

  • 60 / 11

Start / End Page

  • 1250 - 1258

PubMed ID

  • 16950222

Electronic International Standard Serial Number (EISSN)

  • 1873-2402

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/j.biopsych.2006.03.078


  • eng