Skip to main content
Journal cover image

Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype.

Publication ,  Journal Article
Bertolino, A; Rubino, V; Sambataro, F; Blasi, G; Latorre, V; Fazio, L; Caforio, G; Petruzzella, V; Kolachana, B; Hariri, A; Meyer-Lindenberg, A ...
Published in: Biological psychiatry
December 2006

Studies in humans and in animals have demonstrated that a network of brain regions is involved in performance of declarative and recognition memory tasks. This network includes the hippocampal formation (HF) as well as the ventrolateral prefrontal cortex (VLPFC). Studies in animals have suggested that the relationship between these brain regions is strongly modulated by dopamine.Using fMRI in healthy humans matched for a series of demographic and genetic variables, we studied the effect of the COMT val158met polymorphism on function of HF and VLPFC as well as on their functional coupling during recognition memory.The COMT Val allele was associated with: relatively poorer performance at retrieval; reduced recruitment of neuronal resources in HF and increased recruitment in VLPFC during both encoding and retrieval; and unfavorable functional coupling between these two regions at retrieval. Moreover, functional coupling during retrieval was predictive of behavioral accuracy.These results shed new light on individual differences in responsivity and connectivity between HF and VLPFC related to genetic modulation of dopamine, a mechanism accounting at least in part for individual differences in recognition memory performance.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Biological psychiatry

DOI

EISSN

1873-2402

ISSN

0006-3223

Publication Date

December 2006

Volume

60

Issue

11

Start / End Page

1250 / 1258

Related Subject Headings

  • Valine
  • Recognition, Psychology
  • Psychiatry
  • Prefrontal Cortex
  • Oxygen
  • Neuropsychological Tests
  • Neural Pathways
  • Methionine
  • Mental Recall
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bertolino, A., Rubino, V., Sambataro, F., Blasi, G., Latorre, V., Fazio, L., … Scarabino, T. (2006). Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype. Biological Psychiatry, 60(11), 1250–1258. https://doi.org/10.1016/j.biopsych.2006.03.078
Bertolino, Alessandro, Valeria Rubino, Fabio Sambataro, Giuseppe Blasi, Valeria Latorre, Leonardo Fazio, Grazia Caforio, et al. “Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype.Biological Psychiatry 60, no. 11 (December 2006): 1250–58. https://doi.org/10.1016/j.biopsych.2006.03.078.
Bertolino A, Rubino V, Sambataro F, Blasi G, Latorre V, Fazio L, et al. Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype. Biological psychiatry. 2006 Dec;60(11):1250–8.
Bertolino, Alessandro, et al. “Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype.Biological Psychiatry, vol. 60, no. 11, Dec. 2006, pp. 1250–58. Epmc, doi:10.1016/j.biopsych.2006.03.078.
Bertolino A, Rubino V, Sambataro F, Blasi G, Latorre V, Fazio L, Caforio G, Petruzzella V, Kolachana B, Hariri A, Meyer-Lindenberg A, Nardini M, Weinberger DR, Scarabino T. Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype. Biological psychiatry. 2006 Dec;60(11):1250–1258.
Journal cover image

Published In

Biological psychiatry

DOI

EISSN

1873-2402

ISSN

0006-3223

Publication Date

December 2006

Volume

60

Issue

11

Start / End Page

1250 / 1258

Related Subject Headings

  • Valine
  • Recognition, Psychology
  • Psychiatry
  • Prefrontal Cortex
  • Oxygen
  • Neuropsychological Tests
  • Neural Pathways
  • Methionine
  • Mental Recall
  • Male