Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style.
Published
Journal Article
BACKGROUND: In the brain, processing of fearful stimuli engages the amygdala, and the variability of its activity is associated with genetic factors as well as with emotional salience. The objective of this study was to explore the relevance of personality style for variability of amygdala response. METHODS: We studied two groups (n=14 in each group) of healthy subjects categorized by contrasting cognitive styles with which they attribute salience to fearful stimuli: so-called phobic prone subjects who exaggerate potential environmental threat versus so-called eating disorders prone subjects who tend to be much less centered around fear. The two groups underwent functional magnetic resonance imaging (fMRI) at 3T during performance of a perceptual task of threatening stimuli and they were also matched for the genotype of the 5' variable number tandem repeat (VNTR) polymorphism in the serotonin transporter. RESULTS: The fMRI results indicated that phobic prone subjects selectively recruit the amygdala to a larger extent than eating disorders prone subjects. Activity in the amygdala was also independently predicted by personality style and genotype of the serotonin transporter. Moreover, brain activity during a working memory task did not differentiate the two groups. CONCLUSIONS: The results of the present study suggest that aspects of personality style are rooted in biological responses of the fear circuitry associated with processing of environmental information.
Full Text
Duke Authors
Cited Authors
- Bertolino, A; Arciero, G; Rubino, V; Latorre, V; De Candia, M; Mazzola, V; Blasi, G; Caforio, G; Hariri, A; Kolachana, B; Nardini, M; Weinberger, DR; Scarabino, T
Published Date
- June 2005
Published In
Volume / Issue
- 57 / 12
Start / End Page
- 1517 - 1525
PubMed ID
- 15953488
Pubmed Central ID
- 15953488
Electronic International Standard Serial Number (EISSN)
- 1873-2402
International Standard Serial Number (ISSN)
- 0006-3223
Digital Object Identifier (DOI)
- 10.1016/j.biopsych.2005.02.031
Language
- eng