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Beyond taxanes: a review of novel agents that target mitotic tubulin and microtubules, kinases, and kinesins.

Publication ,  Journal Article
Harrison, MR; Holen, KD; Liu, G
Published in: Clin Adv Hematol Oncol
January 2009

Until recently, development of chemotherapeutic agents that target mitosis has centered on inhibiting the mitotic spindle through interactions with microtubules. The taxanes, while significantly advancing the treatment of many types of cancer, suffer from problems of hematopoeitic and neurologic toxicities, development of resistance, and an inconvenient formulation. Novel microtubule inhibitors currently in clinical trial and in clinical use have the main advantage of overcoming resistance. Still, they have side effects related to the inhibition of microtubules in normal host cells. Novel antimitotics, which target the mitotic spindle through interactions with nonmicrotubule mitotic mediators like mitotic kinases and kinesins, have been identified and are now in clinical trial. They offer the prospect of surmounting more of the problems inherent with taxanes and the hope of improving upon their broad antitumor efficacy. This review will concentrate on novel agents in later clinical development that target both the spindle microtubule and nonmicrotubule constituents of mitosis.

Duke Scholars

Published In

Clin Adv Hematol Oncol

ISSN

1543-0790

Publication Date

January 2009

Volume

7

Issue

1

Start / End Page

54 / 64

Location

United States

Related Subject Headings

  • Tubulin
  • Taxoids
  • Protein Kinase Inhibitors
  • Phosphotransferases
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mitosis
  • Microtubules
  • Kinesins
  • Humans
 

Citation

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Harrison, M. R., Holen, K. D., & Liu, G. (2009). Beyond taxanes: a review of novel agents that target mitotic tubulin and microtubules, kinases, and kinesins. Clin Adv Hematol Oncol, 7(1), 54–64.
Harrison, Michael R., Kyle D. Holen, and Glenn Liu. “Beyond taxanes: a review of novel agents that target mitotic tubulin and microtubules, kinases, and kinesins.Clin Adv Hematol Oncol 7, no. 1 (January 2009): 54–64.
Harrison MR, Holen KD, Liu G. Beyond taxanes: a review of novel agents that target mitotic tubulin and microtubules, kinases, and kinesins. Clin Adv Hematol Oncol. 2009 Jan;7(1):54–64.
Harrison, Michael R., et al. “Beyond taxanes: a review of novel agents that target mitotic tubulin and microtubules, kinases, and kinesins.Clin Adv Hematol Oncol, vol. 7, no. 1, Jan. 2009, pp. 54–64.
Harrison MR, Holen KD, Liu G. Beyond taxanes: a review of novel agents that target mitotic tubulin and microtubules, kinases, and kinesins. Clin Adv Hematol Oncol. 2009 Jan;7(1):54–64.

Published In

Clin Adv Hematol Oncol

ISSN

1543-0790

Publication Date

January 2009

Volume

7

Issue

1

Start / End Page

54 / 64

Location

United States

Related Subject Headings

  • Tubulin
  • Taxoids
  • Protein Kinase Inhibitors
  • Phosphotransferases
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mitosis
  • Microtubules
  • Kinesins
  • Humans