Tests for 2 × 2 tables in clinical trials
Five standard tests are compared: chi-squared, Fisher's exact, Yates' correction, Fisher's exact mid-p, and Barnard's. Yates' is always inferior to Fisher's exact. Fisher's exact is so conservative that one should look for alternatives. For certain sample sizes, Fisher's mid-p or Barnard's test maintain the nominal alpha and have superior power. Copyright © 2007 JMASM, Inc.
Hasselblad, V; Lokhnygina, Y
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