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Haplotype-based analysis: a summary of GAW16 Group 4 analysis.

Publication ,  Journal Article
Hauser, E; Cremer, N; Hein, R; Deshmukh, H
Published in: Genet Epidemiol
2009

In this summary article, we describe the contributions included in the haplotype-based analysis group (Group 4) at the Genetic Analysis Workshop 16, which was held in September 17-20, 2008. Our group applied a large number of haplotype-based methods in the context of genome-wide association studies. Two general approaches were applied: a two-stage approach that selected significant single-nucleotide polymorphisms (SNPs) in the first stage and then created haplotypes in the second stage and genome-wide analysis of smaller sets of SNPs selected by sliding windows or estimating haplotype blocks. Genome-wide haplotype analyses performed in these ways were feasible. The presence of the very strong chromosome 6 association in the North American Rheumatoid Arthritis Consortium data was detected by every method, and additional analyses attempted to control for this strong result to allow detection of additional haplotype associations.

Duke Scholars

Published In

Genet Epidemiol

DOI

EISSN

1098-2272

Publication Date

2009

Volume

33 Suppl 1

Issue

Suppl 1

Start / End Page

S24 / S28

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Molecular Epidemiology
  • Linkage Disequilibrium
  • Humans
  • Haplotypes
  • HLA Antigens
  • Genome-Wide Association Study
  • Epidemiology
  • Chromosomes, Human, Pair 6
  • Arthritis, Rheumatoid
 

Citation

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ICMJE
MLA
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Hauser, E., Cremer, N., Hein, R., & Deshmukh, H. (2009). Haplotype-based analysis: a summary of GAW16 Group 4 analysis. Genet Epidemiol, 33 Suppl 1(Suppl 1), S24–S28. https://doi.org/10.1002/gepi.20468
Hauser, Elizabeth, Nadine Cremer, Rebecca Hein, and Harshal Deshmukh. “Haplotype-based analysis: a summary of GAW16 Group 4 analysis.Genet Epidemiol 33 Suppl 1, no. Suppl 1 (2009): S24–28. https://doi.org/10.1002/gepi.20468.
Hauser E, Cremer N, Hein R, Deshmukh H. Haplotype-based analysis: a summary of GAW16 Group 4 analysis. Genet Epidemiol. 2009;33 Suppl 1(Suppl 1):S24–8.
Hauser, Elizabeth, et al. “Haplotype-based analysis: a summary of GAW16 Group 4 analysis.Genet Epidemiol, vol. 33 Suppl 1, no. Suppl 1, 2009, pp. S24–28. Pubmed, doi:10.1002/gepi.20468.
Hauser E, Cremer N, Hein R, Deshmukh H. Haplotype-based analysis: a summary of GAW16 Group 4 analysis. Genet Epidemiol. 2009;33 Suppl 1(Suppl 1):S24–S28.
Journal cover image

Published In

Genet Epidemiol

DOI

EISSN

1098-2272

Publication Date

2009

Volume

33 Suppl 1

Issue

Suppl 1

Start / End Page

S24 / S28

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Molecular Epidemiology
  • Linkage Disequilibrium
  • Humans
  • Haplotypes
  • HLA Antigens
  • Genome-Wide Association Study
  • Epidemiology
  • Chromosomes, Human, Pair 6
  • Arthritis, Rheumatoid