Expression of the 71 kDa dystrophin isoform (Dp71) evaluated by gene targeting.

Journal Article (Journal Article)

To investigate the function of the major non-muscle dystrophin isoform, Dp71, we substituted a beta-galactosidase (betagal) reporter gene for Dp71 by homologous recombination in embryonic stem cells. Staining for betagal activity in chimeric mice revealed Dp71 promoter activity in glial cells in the CNS, in neurons of the inner nuclear and inner plexiform layers of the retina, and in the kidney tubules and collecting ducts. Our observations demonstrate that Dp71 is widely expressed in the adult CNS (retina, cerebellum, cerebral cortex, ependyma, and choroid) as well as the adult kidney epithelium and suggest a broad function for Dp71 in differentiated tissues.

Full Text

Duke Authors

Cited Authors

  • Lumeng, CN; Hauser, M; Brown, V; Chamberlain, JS

Published Date

  • May 29, 1999

Published In

Volume / Issue

  • 830 / 1

Start / End Page

  • 174 - 178

PubMed ID

  • 10350571

Pubmed Central ID

  • 10350571

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/s0006-8993(99)01201-9


  • eng

Conference Location

  • Netherlands