Phase I evaluation of crisnatol (BWA770U mesylate) on a monthly extended infusion schedule.

Published

Journal Article

Crisnatol is an arylmethylaminopropanediol derivative that has shown promise as an antitumor agent in preclinical testing. In a phase I trial using a monthly six-hour infusion schedule the recommended dose for future phase II trials was found to be 388 mg/m2. Neurologic toxicity was dose-limiting in that trial and correlated with the attainment of a threshold plasma concentration of greater than 4.5 micrograms/ml. In this study we treated 15 patients with escalating doses of crisnatol from 450 mg/m2 to 900 mg/m2 administered at a rate of 50 mg/m2/hr over 9, 12, 15, and 18 hours. Toxicity was mild to moderate at all dose levels. However, serious central nervous system effects were noted in one patient at 900 mg/m2 over 18 hours whose plasma level was 6.5 micrograms/ml. This study has demonstrated higher total doses of crisnatol can be given if the drug is administered as a prolonged infusion in an attempt to avoid high plasma levels of the agent.

Full Text

Cited Authors

  • Cobb, PW; Havlin, KA; Kuhn, JG; Craig, JB; Harman, GS; Luther, JS; Turner, JN; Weiss, GR; Tweedy, DA; Koeller, J

Published Date

  • 1991

Published In

Volume / Issue

  • 7 / 2

Start / End Page

  • 85 - 91

PubMed ID

  • 1754731

Pubmed Central ID

  • 1754731

International Standard Serial Number (ISSN)

  • 1043-0733

Digital Object Identifier (DOI)

  • 10.1089/sct.1991.7.85

Language

  • eng

Conference Location

  • United States