Borg proteins control septin organization and are negatively regulated by Cdc42.

Published

Journal Article

The Cdc42 GTPase binds to numerous effector proteins that control cell polarity, cytoskeletal remodelling and vesicle transport. In many cases the signalling pathways downstream of these effectors are not known. Here we show that the Cdc42 effectors Borg1 to Borg3 bind to septin GTPases. Endogenous septin Cdc10 and Borg3 proteins can be immunoprecipitated together by an anti-Borg3 antibody. The ectopic expression of Borgs disrupts normal septin organization. Cdc42 negatively regulates this effect and inhibits the binding of Borg3 to septins. Borgs are therefore the first known regulators of mammalian septin organization and provide an unexpected link between the septin and Cdc42 GTPases.

Full Text

Duke Authors

Cited Authors

  • Joberty, G; Perlungher, RR; Sheffield, PJ; Kinoshita, M; Noda, M; Haystead, T; Macara, IG

Published Date

  • October 1, 2001

Published In

Volume / Issue

  • 3 / 10

Start / End Page

  • 861 - 866

PubMed ID

  • 11584266

Pubmed Central ID

  • 11584266

International Standard Serial Number (ISSN)

  • 1465-7392

Digital Object Identifier (DOI)

  • 10.1038/ncb1001-861

Language

  • eng

Conference Location

  • England