Isolation of cholesterol-dependent Candida glabrata from clinical specimens.


Journal Article

In the past few years, we have detected in the United Kingdom and in the United States several isolates of Candida glabrata that grew poorly unless bile was available. Cholesterol, a component of bile, stimulated equivalent growth of the bile-dependent isolates. The bile-dependent C. glabrata isolates appeared resistant to amphotericin B, but their resistance to fluconazole was unclear. These results demonstrate that occasional isolates of C. glabrata require cholesterol to grow, they may not be detected in specimens set up on standard primary plating media, and they may be difficult to eradicate in patients with antifungal agents directed against ergosterol and its synthetic pathway.

Full Text

Cited Authors

  • Hazen, KC; Stei, J; Darracott, C; Breathnach, A; May, J; Howell, SA

Published Date

  • May 2005

Published In

Volume / Issue

  • 52 / 1

Start / End Page

  • 35 - 37

PubMed ID

  • 15878440

Pubmed Central ID

  • 15878440

Electronic International Standard Serial Number (EISSN)

  • 1879-0070

International Standard Serial Number (ISSN)

  • 0732-8893

Digital Object Identifier (DOI)

  • 10.1016/j.diagmicrobio.2004.12.006


  • eng