Inhibition of Candida albicans attachment to extracellular matrix by antibodies which recognize hydrophobic cell wall proteins.


Journal Article

Cell surface hydrophobicity influences the adhesive properties of the opportunistic fungal pathogen Candida albicans. Hydrophobic proteins are present in the C. albicans cell wall. These proteins were used to generate a polyclonal antiserum and monoclonal antibodies. We characterized three of these monoclonal antibodies (designated 6C5, 5F8 and 5D8) that recognize different hydrophobic cell wall proteins. Initial characterization of the three antigens, and assessment of their distribution among various Candida species was also carried out. Further, pretreatment of germ tube initials with the mAb inhibits binding of these cells to immobilized extracellular matrix. These results suggest that these hydrophobic proteins are involved in C. albicans adhesion events.

Full Text

Cited Authors

  • Masuoka, J; Wu, G; Glee, PM; Hazen, KC

Published Date

  • July 1999

Published In

Volume / Issue

  • 24 / 4

Start / End Page

  • 421 - 429

PubMed ID

  • 10435761

Pubmed Central ID

  • 10435761

Electronic International Standard Serial Number (EISSN)

  • 1574-695X

International Standard Serial Number (ISSN)

  • 0928-8244

Digital Object Identifier (DOI)

  • 10.1016/s0928-8244(99)00059-0


  • eng