Paraquat induced thiol modulation of Histoplasma capsulatum morphogenesis.


Journal Article

Cysteine metabolism with the subsequent release of anionic thiols has been shown to be involved in yeast cell morphogenesis of the dimorphic, pathogenic fungus Histoplasma capsulatum. Following transfer to fresh medium, intracellular thiol levels during the initial 2-4 h appear to determine the eventual growth form. Mild oxidative stress induced by paraquat (methyl viologen) caused enhanced intracellular and extracellular thiol production and an increase in protein thiol formation. Mildly stressed cells continued to grow in the yeast form. Severe oxidative stress induced by high concentrations of paraquat resulted in lowered thiol production as well as reversion to the alternate mycelial morphology. These results suggest that thiol modulation of intracellular protein status may be involved in morphogenesis of H. capsulatum.

Full Text

Cited Authors

  • Leith, KM; Hazen, KC

Published Date

  • July 1988

Published In

Volume / Issue

  • 103 / 1

Start / End Page

  • 21 - 27

PubMed ID

  • 3173469

Pubmed Central ID

  • 3173469

Electronic International Standard Serial Number (EISSN)

  • 1573-0832

International Standard Serial Number (ISSN)

  • 0301-486X

Digital Object Identifier (DOI)

  • 10.1007/bf00437217


  • eng