Temperature-modulated physiological characteristics of Candida albicans.


Journal Article

Despite numerous investigations on candidiasis, definitive conclusions concerning virulence factors are few because of oftentimes confusing and contradictory results. By utilizing various physiologic tests, which include germ tube induction, inhibition of germination by a morphogenic autoregulatory substance, enzyme production, susceptibility to exogenous chemicals, and cell surface hydrophobicity, we demonstrated that such variability is due, in part, to the environmental conditions in which cells were grown in preparation for analysis. Room-temperature grown cells were generally less sensitive to environmental perturbation and germinated more uniformly than cells grown at 37 degrees C. The implication of these results in relation to pathogenic studies and the epidemiology of candidiasis is suggested.

Full Text

Cited Authors

  • Hazen, KC; Hazen, BW

Published Date

  • January 1987

Published In

Volume / Issue

  • 31 / 6

Start / End Page

  • 497 - 508

PubMed ID

  • 3312971

Pubmed Central ID

  • 3312971

Electronic International Standard Serial Number (EISSN)

  • 1348-0421

International Standard Serial Number (ISSN)

  • 0385-5600

Digital Object Identifier (DOI)

  • 10.1111/j.1348-0421.1987.tb03112.x


  • eng