The role of apoptosis in the development and function of T lymphocytes.

Journal Article (Journal Article;Review)

Apoptosis plays an essential role in T cell biology. Thymocytes expressing nonfunctional or autoreactive TCRs are eliminated by apoptosis during development. Apoptosis also leads to the deletion of expanded effector T cells during immune responses. The dysregulation of apoptosis in the immune system results in autoimmunity, tumorogenesis and immunodeficiency. Two major pathways lead to apoptosis: the intrinsic cell death pathway controlled by Bcl-2 family members and the extrinsic cell death pathway controlled by death receptor signaling. These two pathways work together to regulate T lymphocyte development and function.

Full Text

Duke Authors

Cited Authors

  • Zhang, N; Hartig, H; Dzhagalov, I; Draper, D; He, YW

Published Date

  • October 2005

Published In

Volume / Issue

  • 15 / 10

Start / End Page

  • 749 - 769

PubMed ID

  • 16246265

International Standard Serial Number (ISSN)

  • 1001-0602

Digital Object Identifier (DOI)

  • 10.1038/


  • eng

Conference Location

  • England