Profiling a killer, the development of Cryptococcus neoformans.

Journal Article (Journal Article;Review)

The ability of fungi to transition between unicellular and multicellular growth has a profound impact on our health and the economy. Many important fungal pathogens of humans, animals, and plants are dimorphic, and the ability to switch between morphological states has been associated with their virulence. Cryptococcus neoformans is a human fungal pathogen that causes life-threatening meningoencephalitis in immunocompromised and, in some cases, immunocompetent hosts. Cryptococcus neoformans grows vegetatively as a budding yeast and switches to hyphal growth during the sexual cycle, which is important in the study of cryptococcal pathogenicity because spores resulting from sexual development are infectious propagules and can colonize the lungs of a host. In addition, sexual reproduction contributes to the genotypic variability of Cryptococcus species, which may lead to increased fitness and virulence. Despite significant advances in our understanding of the mechanisms behind the development of C. neoformans, our knowledge is still incomplete. Recent studies have led to the emergence of many intriguing questions and hypotheses. In this review, we describe and discuss the most interesting aspects of C. neoformans development and address their impact on pathogenicity.

Full Text

Duke Authors

Cited Authors

  • Kozubowski, L; Heitman, J

Published Date

  • January 2012

Published In

Volume / Issue

  • 36 / 1

Start / End Page

  • 78 - 94

PubMed ID

  • 21658085

Pubmed Central ID

  • PMC3318972

Electronic International Standard Serial Number (EISSN)

  • 1574-6976

Digital Object Identifier (DOI)

  • 10.1111/j.1574-6976.2011.00286.x


  • eng

Conference Location

  • England